Trimethylglycine, commonly known as TMG, is a compound that occurs naturally in the body, in certain foods, and is available as a supplement. It is a methylated form of the amino acid glycine, meaning it has additional methyl groups that can be donated for various bodily functions.

Methylation is a biochemical process that influences gene expression and other DNA functions. By donating methyl groups, TMG helps the body adapt and maintain healthy cellular functions, which can contribute to longevity, muscle building, and fat loss.

Research indicates that TMG supplementation may significantly reduce fat mass and body fat percentage without affecting overall body weight. This suggests that TMG might help in burning fat while conserving or even increasing muscle mass, a finding traditionally associated with performance-enhancing drugs.

• A study in the journal Nutrients found a noticeable decrease in fat mass with TMG.
• Increased muscle mass observed without significant weight gain.
• Potential inhibition of intramyocellular triglycerides, reducing fat storage in muscles.

TMG is naturally present in several foods. Beets are a rich source, aligning well with additional benefits from their high nitric oxide content. Other sources include shrimp, spinach, and particularly wheat bran, though consumers with gluten sensitivity should exercise caution with the latter.

Nicotinamide mononucleotide (NMN), often used to boost cellular energy levels, can deplete methyl groups when increasing NAD+ levels. Introducing TMG may prevent such depletion, enhancing both energy production and methylation processes.

Preliminary studies suggest TMG might support gut barrier integrity by modulating proteins that enhance gut lining strength, potentially offering solutions for issues like leaky gut.

"There is some interesting literature starting to come out that suggests that TMG improves gut barrier integrity."

TMG is a promising supplement that may support various health aspects from fat loss and muscle building to improved longevity and gut health. It can be integrated through dietary sources or supplements, offering a multifaceted approach to wellness.

As always, further research and personalized advice from health professionals are recommended to fully leverage TMG's benefits.